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Similar content being viewed by others Introduction Diabetes mellitus (DM) is a multi-factorial metabolic disease which involve multiple genes and environmental factors, as well as other metabolic disorders such as obesity and insulin resistance, which is estimated to affect 578 million people worldwide by 2030 1,2

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Under typical circumstances, the body sustains a balance between oxidation and antioxidation, preventing ROS overaccumulation and subsequent disruption of bone metabolism