O'Brien S, Giles F, Talpaz M, Cortes J, Rios MB, Shan J, Thomas D, Andreeff M , Kornblau S, Faderl S, Garcia-Manero G, White K, Mallard S, Freireich E, Kantarjian HM
One critical error we see repeatedly: researchers assume 'more water is safer' because it dilutes the peptide
The study focused on 5 specific immune-related adverse events, based on the National Comprehensive Cancer Networks (NCCN) guidelines for the management of immunotherapy-related toxicities, version 1.2020, including diarrhea/colitis, kidney injury, pneumonitis, thyroid disorder, and transaminitis
Efficiency IV therapy is more efficient than oral supplements
Regulatory agencies are scrambling
Theranostics 7 , 10361046 (2017)