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Los pacientes fueron sometidos a una intervencin intensiva del estilo de vida de 12 semanas, y aquellos que haban perdido un 5% del peso fueron aleatorizados a placebo vs frmaco durante 72 semanas (dosis del frmaco: 2,5 mg/semanal con aumento cada 4 semanas hasta un mximo de 15 mg/semana o dosis mxima tolerada)

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