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High-frequency stimulation induces gradual immediate early gene expression in maturing adult-generated hippocampal granule cells

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A provider may recommend slower dose escalation to minimize glycosuria exposure during the titration phase, or may defer treatment pending fungal assessment if baseline risk is very high

Dihexa's preclinical design emphasized brain penetration, and animal studies showed CNS effects

Wegovy's most frequently reported adverse effects include nausea (occurring in up to 44% of patients), vomiting, diarrhoea, constipation, and abdominal pain

In combination, these effects might make it harder for some people to tolerate both drugs