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Monitoring Requirements When Combining GLP-1 and Anticoagulants Patients using both semaglutide and blood thinners should schedule INR (International Normalized Ratio) tests more frequently during the first 4-6 weeks of GLP-1 therapy initiation or dose escalation

If successful, they could dramatically improve convenience and potentially increase treatment uptake

Difficult timing: John explains that oral semaglutide must be taken on an empty stomach and requires a 30-minute wait before eating, which can be hard to maintain long-term

2018;7:60112.e3

Approved in April 2026, it offers the flexibility of daily oral consumption without food or water restrictions

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