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Int J Pharm 379:100108

Strong responders who maintain improvements well during breaks may extend break periods

Maintaining consistent medication schedules for dogs can be challenging, particularly for long-term treatments (e.g., parasite prevention and arthritis pain medication) and chronic conditions requiring daily administration (e.g., allergic dermatitis)

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Using simple sterile water is acceptable only if you plan to use the entire vial in a single session, as it contains no preservative to inhibit bacterial growth