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Regarding the serum GLP-1 and insulin levels, the levels of GLP-1 in T2DM and T2DM + sham group were significantly lower than NC group, compared with the T2DM + sham group, GLP-1 levels increased dramatically in T2DM + RYGB and T2DM + EX-4 groups (Figure 6H)
The GLP-1RAs are achieving blockbuster status, meaning a drug that generates yearly sales exceeding one billion dollars for a drug company
Endocrinologists do not normally applaud slide decks
For patients seeking pronounced results from GLP-1 receptor agonist therapy in terms of shedding pounds, they may opt instead for different receptor agonists that promise greater outcomes
A major trial found that semaglutide, sold as Ozempic and Wegovy, cut cardiovascular deaths by about a fifth in some patients
Phase II Clinical Data Jastreboff 2023 (NEJM) reported 24.2% bodyweight reduction at 48 weeks - the largest effect size published for any metabolic peptide in clinical trials
