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Wadden, T

Less commonly, nausea, fatigue, or sleep changes may occur during early doses

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The compound could theoretically interact with medications affecting NAD+ metabolism, energy pathways, or the enzymes responsible for its clearance from the body

National Library of Medicine: Indeed, DNA synthesis is impaired by low vitamin B12, which hampers the activation of folate and, as a result, decreases normal red blood cell production, impairing oxygen delivery [62] WebMD indicates, if you have vitamin B12 deficiency, you could become anemic

Many IC/BPS patients suffer from other chronic pain conditions as well