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The covalent conjugation of a drug with a biotin ligase enables targeted biotinylation and identification of the drug-bound proteome
The gut microbiome can also play a significant role in how conjugated toxins are moved out through feces or absorbed back into the body.[ref] ABCB1 P-gp efflux transporter for medications, HRT, and environmental toxins SLCO1B1 and ABCG2 statins and muscle pain risk OCTN1 organic cation transporter, ergothionine Detoxification pathways for specific substances: In addition to the phase I and phase II specific genes above, the following articles look at specific toxicants and their detoxification pathways: Mold Genes Arsenic Detoxification BPA Detoxification Glyphosate Detoxification Organophosphate Pesticides Caffeine Metabolism Phthalate Detoxification Lead PFAS Fluoride DPYD 5-fluorouracil toxicity Mercury Molybdenum and copper ALDH2, ADH1B and Alcohol By learning about your genetic variants and their impact on detoxification pathways, you can take proactive steps to support your bodys natural ability to eliminate harmful substances and maintain optimal health
Another study in agricultural workers from East Texas identified a significant increased risk (OR = 10.9) of PD with the continuous use of rotenone [53]
D., Hayes-Larson, E., Morris, E
