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PYC modulates TGF-1 expression and the phosphorylation of SMAD (mothers against decapentaplegic homolog) family member 2/3, effectively suppressing these signaling pathways (Ko et al., 2017)

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However, staying hydrated and maintaining regular physical activity supports overall metabolic health during the clearance window

This usually includes evidence of a BMI above 27 with comorbidities (hypertension, diabetes, sleep apnea) or BMI above 30, plus documentation of failed prior weight loss interventions