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Evidence includes: Stimulation of endothelial and keratinocyte migration Enhanced blood vessel density in wound healing models Promotion of stem cell differentiation toward repair cell lineages Low molecular weight enabling tissue penetration over long distances Unlike growth factors that bind to extracellular matrix, TB-500s mobility allows systemic distribution to multiple injury sites

doi: 10.1016/j.tips.2005.09.002

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In fact, a strong argument can be made that B12/MIC is a particularly versatile inhibitor of mTOR precisely because its various components each work to combat distinct catalysts of mTOR stimulation

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