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This makes it an attractive drug to treat many of the cardiometabolic parameters that we are interested in. Assessing the STEPs For the four phase 3 STEP trials (Table), researchers assessed semaglutide 2.4 mg in more than 4,300 adults with obesity or overweight with a weight-related comorbid condition

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The slight potential reduction comes from lower peak concentrations, but this is partially offset by higher trough levels providing more consistent appetite suppression

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The formulation patent may issue and may withstand IPR proceedings, but the commercial life is constrained by formulary placement