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Description

B12 depletion is a documented concern during semaglutide therapy, with research showing that GLP-1 medications can reduce intrinsic factor and impair B12 absorption in the terminal ileum

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The approach to treatment is typically conservative at first, including non-surgical interventions like wrist splinting, avoidance of activities that might exacerbate the condition, and nonsteroidal anti-inflammatory drugs (NSAIDs) for pain relief

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Long-term sustainable change: Patient is willing to invest 3 to 6 months for durable metabolic improvement

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The challenge will be to balance GI tolerability, insurance coverage, and the need for chronic injectable therapy

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