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Important precautions Lactic acidosis Metformin can cause a rare but serious build-up of acid in the blood

In clinical trials, nearly half of people, 44%, who took Wegovy reported nausea, and almost 1 in 4 reported vomiting

Research shows similar rates of diarrhea whether or not patients were taking metformin alongside their GLP-1 therapy

10.1038/nrn3335 18 DasU.KumarJ.MayerM

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The results, published in The New England Journal of Medicine in September 2025, showed that orforglipron is safe and effective for weight lossand offers additional cardiovascular benefits