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Most data are preclinical
The FOXO4p53 axis in senescence p53 is a major tumour suppressor and master regulator of cellular stress responses: DNA damage, oxidative stress, oncogene activation
One of the most intriguing observations in this context was the desensitization of cells pretreated with NFT for glutathione induction in response to secondary stressors
In particular, vaginolysin [198], intermedilysin [198], and high glucose concentrations combined with pore-forming toxins [200] induce necroptosis of erythrocytes at concentrations that dont induce eryptosis
Injection Maintenance After initial therapy (23 months, 12 injections weekly), maintenance injections are taken once every 24 weeks
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