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JCI Insight , 7(13)

Current evidence suggests GLP-1 receptor agonists have a neutral effect on fracture risk, though bone mineral density changes may occur indirectly through substantial weight loss

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However, the administration of semaglutide appeared to block this process, potentially leading to a diminished alcohol-induced reward and punishment response within the body.433 Remarkably, compared with untreated rats, treated rats exhibited a significant reduction in alcohol intake, which was reduced by half.433 These findings highlight the potential therapeutic efficacy of semaglutide in mitigating alcohol consumption.434 Interestingly, a clinical study published in Nature Metabolism in 2023 investigated the restorative effects of liraglutide on impaired associative learning in individuals with obesity

The solution was stirred at room temperature for 1 h

The results showed fewer heavy-drinking days and lower overall alcohol consumption compared to placebo