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The trade-offs are regulatory complexity, variation in oversight, and a shifting FDA posture after the 2024 shortage resolution
Abeyta says the move to an oral GLP-1 feels like a major shift for accessibility
doi: 10.3389/fendo.2019.00155 129 DuarteAICandeiasECorreiaSCSantosRXCarvalhoCCardosoSet al
This was supported by Bester et al., who demonstrated that IL-1, IL-6, and IL-8 (proinflammatory cytokines) promote whole-blood hypercoagulability and alter erythrocyte membrane structure
The clotting risk piece is the one most patients have not thought about
Its a big topic and physicians want to know: Do I really need to focus on these? The lack of improvement in fibrosis with GLP-1s was demonstrated in a 2020 study published in The New England Journal of Medicine, in which patients with MASH and stage 2 or 3 fibrosis were randomly assigned to once-daily semaglutide (Ozempic, Wegovy
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