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Available in injectable and oral forms, dosing varies

So, as this group has been experimenting over the last years, the problem with IGF-1 is a matter of dosage

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Potential Side Effects and Precautions B12 injections, generally safe, can cause mild side effects and require professional guidance

"Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls." Journal of pharmaceutical and biomedical analysis 101 (2014): 66-83.

In theory, combining agents that both reduce adiposity and improve insulin sensitivity could produce additive or synergistic metabolic effects but this is entirely speculative and unproven in humans