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[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Traish A.M

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286 It reduces estrogen bioavailability, which can accelerate estrogen depletion and possibly trigger early menopause, as well as aggravate menopausal symptoms

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Studies have shown that the anthracycline drug idarubicin, when used in combination with histone deacetylase inhibitors (such as Vorinostat 0.0751 M or Valproic acid 0.253 mM), significantly enhances synergistic antitumor activity against MOLT4 and HL60 leukemia cell lines and primary acute leukemia patient cells