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The 21-day countdown begins the moment the pen is no longer chilled

Most vomiting episodes happen during the first weeks of treatment or right after a dose increase

Ex-4 also modulates the influx of calcium through L-type voltage-dependent calcium channels (L-VDCCs) and N -methyl-d-aspartate receptors, and it maintains the expression of phosphorylated calcium/calmodulin-dependent protein kinase type II [73]

M.CosgroveR.Alsina-FernandezJ.DograM.et al (2021)

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