However, it is important to note that participants with any substance use disorder other than cannabis or alcohol in the 12 months before enrollment were excluded from MAPP2, as were participants with severe or moderate (in early remission) alcohol or cannabis use disorder
Trials in patients with generalized anxiety disorder and subclinical depression also showed that ashwagandha improved Hamilton Anxiety Rating Scale (HAM-A) and Hamilton Depression Rating Scale (HAM-D) scores [34]
Similarly, we used linear regression to test the correlation between GR conversion and bacterial GR-conversion genes in all samples (both crossover periods) for the GR alone or GR + Myr groups to test the capacity to predict response to GR regardless of the timing of the sample
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