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Fibroblast-like synoviocyte (FLS) are predominant cells of synovia and play a key role in the pathophysiology of joint diseases, thus increasing the expression of proinflammatory mediators

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It was recently found that activating ER stress associated with inositol-requiring kinase enzyme 1 (IRE1)-XBPl and/or the ATF6 signalling pathway caused a fat utilisation disturbance in blunt snout bream, yellow catfish ( Pelteobagrus fulvidraco ) and zebrafish ( Danio rerio ) fed with HFD (Reference Cao, Dai and Liu26Reference Dai, Wang and Zheng28)

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