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The glucose-dependence that makes them safe, the central action that drives weight loss, the cardiovascular and renal benefits, and the gastrointestinal side effects all trace back to where the receptor sits and how it signals

Role of glucagon-like peptides in inflammatory bowel diseases-current knowledge and future perspectives

Cardiovasc Diabetol 22 , 79 (2023)

For example, the standard semaglutide (Wegovy) protocol exponentially escalates the dose every 4 weeks 0.25 mg for 4 weeks, then 0.5 mg, 1.0 mg, 1.7 mg, and finally 2.4 mg/week by about week 16 (source)

Brown adipocyte-specific NKO (BANKO) mice were also established, and their metabolic phenotypes were directly compared with that of ANKO mice

Try a different medication: If you want to keep taking a weight-loss medication but the cost or side effects make GLP-1s a no-go, there are other options out there such as Qsymia and Contrave and your clinician may be able to recommend and prescribe a different weight-loss medication