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However in our opinion, the low probability of MS coincidence with another rare disease, together with the animal studies where MS is never a consideration, makes it more likely that these human examples align with an inside-out model (Figure 2), where a primary biochemical derangement of myelin, coupled with an immune predisposition, culminated in a MS-like phenotype

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Universally known as 'Bobby' Lim was born in Singapore where his father, Lim Boon Keng, practised as a physician and was active in Chinese public affairs

Scientists have found a strong association between the onset of vitiligo and various autoimmune diseases, including hypothyroidism, multiple sclerosis, rheumatoid arthritis, idiopathic thrombocytonpenic purpura, seronegative arthritis, pernicious anemia, myasthenia gravis, inflammatory bowel disease, lymphoma, and systemic lupus erythematosus

2020;53(6): e12829