Because GLP-1 therapies can reduce appetite and overall food intake, maximizing nutrient utilization from smaller meals may be beneficial. Digestive enzymes may also help support digestion and digestive comfort (such as bloating or fullness)
Tirzepatide achieves even larger reductions, up to 2.0 to 2.3 percentage points in clinical trials
Participants on all doses of Foundayo also experienced meaningful reductions in heart disease risk factors, Lilly said, including waist size, cholesterol and triglycerides levels, and blood pressure
On the other hand, prolonged (16 h) stimulation with GLP-1 was shown to promote Hypoxia-Inducible Factor 1 (HIF-1) activity via induction of the mammalian Target of Rapamycin (mTOR) 16
Some formulations also carry indications for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity
These citations are context, not medical advice, proof of eligibility, or a claim that every study applies to every patient