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Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1

The lifespan of an individual with T2DM and a prior myocardial infarction (MI) is shortened further still by 12 years

Except for oral semaglutide, theyre typically subcutaneous injections (administered into the fatty tissue just under the skin)

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Diabetes 54 , 16151625 (2005)

But know that dose modification is a legitimate tool for managing side effects, and a good provider will work with you to find the balance between therapeutic benefit and tolerability