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In addition, due to the low concentration of (poly)phenols in plasma compared to well-known antioxidants such as vitamin C or uric acid, the possibility that (poly)phenols act as direct antioxidants in vivo to improve cardiovascular health is unlikely

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Raised intracellular NAD+ and SAM In cultured adipocytes, NNMT inhibition lowered 1-methylnicotinamide and raised both NAD+ and SAM, the biochemical signature researchers look for when the metabolic sink is blocked [1]

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shRNA and the negative control sequence are listed in Table SI

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