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Krogias, C

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From lifestyle management alone: Individuals adding orforglipron to existing diet and exercise programs should maintain their lifestyle interventions rather than relaxing them

The combination amplifies metabolic stress on the body, making adequate protein intake and hydration even more critical

A separate retrospective study published in 2025 in JAMA Ophthalmology compared patients who took either oral or subcutaneous semaglutide for type 2 diabetes and matched them to control based on race, sex, A1c and comorbid conditions such as DR, sleep apnea, hypertension and hyperlipidemia