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doi: 10.1111/nmo.13546 95 RaybouldHE

A., Lubbers, L

First, BCKAsthe immediate transamination products of BCAAsaccumulate when BCKDH flux is impaired and directly inhibit insulin-stimulated Akt phosphorylation, thereby impairing glucose uptake and mitochondrial oxygen consumption through mTORC1-independent routes ( Figures 2 , 3

Gastric emptying normalizes, appetite-regulating hormones return to pre-treatment patterns, and the metabolic advantages conferred by weight loss begin to diminish as weight is regained

Additionally, since altered tyrosine metabolism has been linked to neuroinflammation 29 its elevation may reflect the dual involvement of neurotransmitter dysregulation and inflammatory pathways in the epileptic process

Apr 1999;18(2):166-70