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Increased root canal endotoxin levels are associated with chronic apical periodontitis, increased oxidative and nitrosative stress, major depression, severity of depression, and a lowered quality of life

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Growth hormone receptors are present on many cell types involved in wound healing, including fibroblasts that produce collagen and keratinocytes that regenerate the skin surface

Notably, VGF suppression led to significant reductions in SCG2 and CHGA levels but did not affect SCG3 expression (Fig