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Consistent with the phosphorylation of Met and the subsequent signalling proteins, the dimeric macrocycles are able to clearly mimic the functional role of hHGF and induce cellular responses in not only model cell lines but also various normal human cells (Figs 4, 5, 6 and Supplementary Figs 13 and 14)

We might expect that even broader variety of resistance mechanisms would be revealed were it to be used in clinical settings

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For anyone running peer-reviewed or grant-funded research, that documentation is the baseline

The effects of Sirt1 on microglial viability were examined using CCK-8 assays following OGD/R injury

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