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The investigators evaluated 12-hour integrated growth hormone secretion (10-minute sampling intervals over 12 hours), serum IGF-1, body composition (skin thickness, lean body mass, body fat), and metabolic parameters at baseline, after placebo, and at 4 and 16 weeks of GHRH analog administration

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(PubMed) Traber MG

WeaverCMMartinBRNakatsuCHArmstrongAPClavijoAMcCabeLDet alGalactooligosaccharides improve mineral absorption and bone properties in growing rats through gut fermentation

This context-dependency implies that the specific effects of senescence might differ across various tissues and diseases