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In fact, they received a patent on their process in 2013

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Murphy MP, Levine H (2010) Alzheimers disease and the amyloid- peptide

In the domain of preclinical wound healing and tissue engineering, accelerating the structural repair of poorly vascularized matrices remains a primary challenge for modern biochemistry

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They are primarily generated through enzymatic reactions involving NADPH oxidases (NOXs), cytochrome P450 reductase (POR), and NADH-cytochrome b5 reductase (CYB5R1), with the mitochondrial electron transport chain (mETC) serving as another significant source (Yan et al., 2021)