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How would the addition of a GLP-1RA compare to other second-line add-on therapies in improving management of the T2DM

Despite the robust body of evidence showing the cardiovascular benefits of GLP-1 RAs, their origins as diabetes/glucose medications and the mode of administration of all but one by subcutaneous injection have posed barriers for cardiologists to adopt them as a routine part of clinical practice

Phase 3 data on retatrutide (triple GLP-1/GIP/glucagon agonist) showing nearly 29% weight loss, the pending approval of CagriSema (GLP-1/amylin combination), and the arrival of oral non-peptide GLP-1 agonists like orforglipron all suggest we are at the start of a metabolic therapeutics renaissance

Do these methods work

If you watched the episodes that we did about testosterone and estrogen, if you watched the episode that I did on male and female fertility, if you watched the episode that I did with Dr