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Participants with normal hepatic function were eligible for inclusion if they were judged to be of general good health by the investigator, based on a medical examination (including physical examination, medical history, vital signs and ECG) and had liver enzyme levels within prespecified limits (alanine aminotransferase upper limit of normal [ULN] + 10%, aspartate aminotransferase ULN + 20% and total bilirubin ULN + 20%)

Repeated, method-validated measurements (scintigraphy or C-breath testing) in the same participants at treatment start and after weeks of steady state, for cagrilintide monotherapy, to test the tachyphylaxis hypothesis directly

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You're not alone, and you're right on schedule for what researchers call "Quitter's Day" - the second Friday in January, when most New Year's resolutions go to die

Nez-Carro C, Blanco-Blanco M, Montoya T, Villagrn-Andrade KM, Hermida-Gmez T, Blanco FJ, et al

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