humanized glp-1 receptor knock-in mouse The Obesity Science & Innovation 2025: Generation of GIPR Mice for Obesity and Diabetes Preclinical GLP-1 Orals and Multi-Agonists: Advancing

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GLP-1 (Glucagon-like peptide-1) injections are a class of medications that mimic the action of the natural GLP-1 hormone in the body, stimulating insulin secretion, suppressing appetite, and delaying gastric emptying, thereby promoting weight loss

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For instance, patients using liraglutide (Saxenda), which is specifically approved for weight loss, typically experience average weight reductions of approximately 57% of their initial body weight after one year

As clinicians, we like solid evidence-based [interventions]. Working holistically GLP-1 agonists, which are more commonly known by popular brand names, Ozempic and Wegovy, are injectable medications that mimic glucagon-like peptide-1, a natural hormone secreted in response to food intake that slows digestion and gives the brain satiety signals

Expert Rev Endocrinol Metab 2025;20:147-52.ArticlePubMed 96