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Severe deficiency can contribute to fatty liver changes, which is one reason choline gets framed as liver support. Details are summarized in the NIH ODS Choline fact sheet for health professionals

This is where compounds like GHK-Cu become interesting

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Recent studies have demonstrated that primary and secondary sites can communicate through exosomes, shed not only by the primary tumor cells, but also by the immune and stromal cells such as NK cells, CAFs and dendritic cells [19]

Tan, D.-X., Chen, L.-D., Poeggeler, B., Manchester, L

Most concerns regarding kidney damage are linked to extremely high-dose intravenous injections used for non-wellness purposes, such as skin whitening, rather than nutritional supplementation