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In classical FAD-responsive disorders such as MADD, high-dose riboflavin given together with carnitine, CoQ10 or -lipoic acid augments -oxidation, rescues exercise capacity and improves acyl-carnitine profiles, outcomes repeatedly documented in small series and case-controlled exercise studies (77, 78)

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The tradeoff is that the multi-receptor activity is locked into the molecule rather than adjustable by mixing