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Dysesthesia, an abnormal sensation often described as tingling, burning, or numbness in the skin, appeared in 8.8% of participants on the 9 mg dose and 20.9% on the 12 mg dose, compared to just 0.7% on placebo

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In a similar model, rats supplemented with zinc had a significant reduction in opened tight junctions when compared with untreated rats with colitis, but no amelioration of clinical disease [157]

Dosage Schedule: The treatment usually starts with an intensive phase (e.g., daily or every other day) to replenish stores, followed by a less frequent maintenance phase (e.g., once a month or once every few months)

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