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35, 36 AMPK activation by anti-diabetic drugs such as metformin is currently considered a beneficial adjunct to standard cancer therapy

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In the agencys own words, it does not have the authority to approve dietary supplements for safety and effectiveness, or to approve their labeling, before the supplements are sold to the public.3 This means that its up to supplement manufacturers to take the necessary steps to ensure consumer safety

For people with documented variants, methylated folate may bypass that conversion step entirely

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Diabetes Care 32 , 12561260 (2009)