Metformin should be temporarily stopped during acute illness, severe dehydration, or before procedures requiring iodinated contrast media to reduce the rare risk of lactic acidosis, and restarted only when renal function is stable
Pediatric Neurology , 110 , 3041
Research published in Nature described MOTS-c as an exercise-induced peptide that translocates to the nucleus and helps regulate metabolic genes (Nature Communications)
Natural compounds and products from an anti-aging perspective
Impaired cerebral autoregulation and the other metrics of cerebral hemodynamics reported by Koch et al (rapid rise in MCA pulsatility, drop in cerebrovascular resistance index) in the immediate post-exercise period align well with the phenomenon of weightlifters blackout in which individuals may experience syncope or pre-syncope immediately following high intensity resistance exercise, particularly when in the upright standing position due to the sudden pressure drop upon release of the external load (Compton et al., 1973)
On non-training days, timing is less critical, so you can take it at any convenient time such as with a meal in the morning
