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Sleep Medicine, 72 , 28-36

From acetaminophen, the P-450 system forms an intermediate metabolite referred to as NAPQI, which turns out to be a toxic compound

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Such a role in mammals is controversial, although sirtuins are energy-sensing regulators involved in signaling pathways that could play important roles in delaying the onset of age-related diseases (e.g., cardiovascular disease, cancer, dementia, arthritis)

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Understanding this connection helps patients and healthcare professionals anticipate and manage this potential side effect effectively, rather than discontinuing a potentially beneficial treatment prematurely