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Hypothalamic tanycytes are glial cells located along the walls and floor of the third ventricle, which are known to play neuroendocrine roles such as detecting and transporting nutrients and hormones like insulin and GLP-1, as well as regulating neuronal activity [60-62]

Antioxidant enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase protect cells against toxic ROS

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The Nrf2 activation along with the thiamine formation may explain why high doses of the thiamine disulfides, expected to decrease cellular redox potential, do not have any negative action even upon the long-term administration (155)

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