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Regulatory Status: Please note that as of early 2026, Retatrutide remains an investigational compound

A Swedish cohort study examined the impact of multiple GLP-1RAs on the incidence of DR in 2,390 diabetic patients

If a patient receives a GLP-1 medication by mail-order pharmacy, they should refrigerate it immediately upon arrival

However, any custom protocol, including microdosing, must be created by a provider

Similarly, a systematic review addressing the perioperative management of diabetic patients endorsed the maintenance of GLP-1RAs treatment on the day of surgery.179 In a single-center retrospective cohort study by Stark et al180 involving patients undergoing esophagogastroduodenoscopy, most of whom had T2DM, 56% received dulaglutide, 37% liraglutide, and 5% exenatide

Reducing body fat decreases mechanical load on joints, while both peptides may support cartilage health