is metformin a glp 1 receptor agonist vs. GLP-1 Agonists: Which Diabetes Medication Right for You? Frontiers | Mini Review: Effect

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However, at high concentrations, when RNS levels exceed the capability of its detoxification in the biological system, serious damage to cells may occur [147, 148] due to inhibition of mitochondrial respiratory function by competing with O 2 for interaction with cytochrome oxidase [149] and via nitrative/nitrosative stress [150, 151]

They can denote early disease processes, detect early signs of drug response or adverse events, and be used to monitor for toxicity or resistance over time