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Focusing on dynamic associations between metabolism and disease stages, longitudinal metabolomic cohort studies can track changes in metabolic profiles of patients from early asymptomatic stages to stable and acute exacerbation phasesidentifying core metabolic characteristics at different disease stages and addressing gaps in the current understanding of correlations between disease staging and metabolic abnormalities

The exact cause of this condition is unidentified however immunological dysregulation, and allergic-like reactions are thought to have a role

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Subjects having CVMI stage 3, 4 or 5 with no growth disturbance, systemic disease, bleeding anomaly, history of long term medication, trauma or surgical intervention in the cervical vertebral region were included in the study

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Physical activity, for instance, can promote digestion and reduce gastrointestinal discomfort