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Epidemiologic studies have shown that high fruit and vegetable intake is associated with a reduced risk of certain cancers, but high doses of carotenoid supplements may be counterproductive in specific populations ( 3.3 Anticancer mechanisms of omega-3 fatty acids 3.3.1 Regulation of inflammatory pathways Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduce the levels of pro-inflammatory cytokines and downregulate inflammatory mediators such as COX-2, TNF-, NF-B, and prostaglandin E2 (PGE 2 ), which attenuates cancer-related inflammatory responses ( 2 and leukotrienes ( Together, these effects reduce tumor-associated pro-inflammatory cytokine release and inflammatory cascade responses, thereby helping to inhibit inflammation-driven tumor progression
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