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In a phase III study, semaglutide resulted in greater than 15% weight reduction from baseline (Wadden et al

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The GLP-1 R is a member of the class B family of G protein-coupled receptors (GPCRs) [35], and investigations have confirmed its expression within the human retina [36]

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Hence, we hypothesised that GLP-1 signalling in the OB could control the neural circuitry that regulates energy homeostasis in the context of metabolic disorders