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Altogether, these data support a pathogenicity mechanism where variants can disrupt transporter gating

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This is part of why the dosing philosophy for tirzepatide starting very low and escalating gradually is so important: the medication is potent, and the body needs time to adapt

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Glucagon-Like peptide-1 receptor PET/CT with 68Ga-NOTA-Exendin-4 for detecting localized insulinoma: A prospective cohort study