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PMCID: PMC6219651

The company describes retatrutide as an investigational once-weekly triple-hormone receptor agonist that activates GIP, GLP-1, and glucagon receptors with a single molecule.[4] This development history is important because retatrutide was designed as a next-generation incretin therapy rather than as a simple modification of an existing GLP-1 agent

Key Health Benefits Beyond Diabetes and Weight Loss a) Cardiovascular Health Clinical trials show GLP-1 drugs lower risks of heart attacks, strokes, and cardiac deaths by improving cholesterol and reducing artery inflammation

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